SOLVER Scanning Probe Microscope

Solver P47BIO

Solver P47BIO scanning probe microscope is a special device for biological and medical applications. It is based on a combination of an inverted optical and a scanning probe microscopes that enables visualisation of a sample surface by optical system during the scanning process in different SPM modes. An inverted optical microscope simplifies adjustment and positioning processes. The device provides investigations in ambient and liquid environment.

Measuring modes:
Contact AFM/ LFM/ contact AFM in liquids/ ResonantMode AFM (semicontact +non contact)/ Phase Imaging/ Force Modulation (viscoelastisity)/ MFM/ EFM/ Adhesion Force Imaging/ Force Spectroscopy/ Spreading Resistance/ SCM/ SKM/ AFM, voltage, RM Lithography

P47BIO applications include imaging of:
DNA and chromatin structure, protein/enzyme interactions, protein adsorption, biomacromolecules, cell surface antigens, intracellular interactions, cell morphology and motility, synaptic release and signal transduction processes, membranes, viruses and other microbes, force measurements.

Solver P47BIO

Technical specification
Sample size 90x90 mm (max)
Scanning area 60x60x3 µm, 100x100x5 µm.
Min scanning step 0.06 A°, 0.1 A°
XY sample positioning 30x30 mm (within 30 mm circle),
1 mm scale count.
Fine cantilever positioning 4x4 mm range, 5 µm resolution.
Optical system inverted microscope and
color CCD camera SONY SSC-DC500P.
Tip viewing scanning cantilever can be viewed on the
monitor screen during the scanning procedure
Magnification
with 14X eyepieces 8.4X to 100X
with color CCD 43X to 470X
Optical microscope:
Resolution 5 µm (with optional objective up to 1.5µm)
Field of view 14X eyepieces 2.4 mm to 28mm
Scanning resolution DAC down X, Y, Z and 16-bit ADC
Frequency range 10 Hz-2 MHz
Accuracy of modulation
frequency setting
digital 32-bit (0.01 Hz).
Sample holder
Vacuum chuck for Petri dishes 60x60 mm and 90x90 mm
Holder with spring
clamp for samples
up to 30x100 mm
Inverted Optical Microscope
Objectives 2.5x0.08; 6.3x0.20; 10x0.22; 20x0.45
Field of view 0.5 mm to 6.2 mm
Magnification with eyepieces 30X to 360X
Bright field, phase contract and polarization cotrast
Trinocular head for CCD camera

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